Endocrine Abstracts

Background and aims: The ratio of TG/ HDL-C can identify cardiometabolic risk and cardiovascular disease. The visceral adiposity index (VAI) is a sex-specific index, in which measurements of body mass index and waist circumference are combined with TG and HDL-C concentrations. T? study association between VAI and TG/HDL-C and the value of TG/HDL-C ratio as a marker of disfunction of visceral adiposity tissue at patients with acromegaly.Subjects and metho...

Introduction: Hyperuricemia is increasingly being considered a potential pathogenic factor for T2DM, metabolic syndrome, and several adverse consequences of vascular disease. It has been suggested that xanthine oxidase may underlie the urine acid-T2DM association. The study aimed to determine the associations between clinical parameters, glucose homeostasis, and SXO activity in patients with T2DM.Methods: 125 patients with T2DM, age (58.9±9.4) years...

The aim: To estimate secretory and proliferative activity of pituitary adenoma (isolated somatotropinoma (ST) and somatomammotropinoma (SMT).Subjects and methods: The study included 133 patients (total group: 45 male/88 female), aged 44.0±12.5 year old with acromegaly (95 – with ST and 38 – with SMT). There were estimated patient’s age, age of manifestation of acromegaly (agemanifest.), duration of period before diagnosis (...

Aim: The aim is to study the clinical and hormonal peculiarities of PROL (prolactinoma), manifesting in people under the age of 18 and monitoring the effectiveness of suppressive CAB (Cabergoline, Dostinex) therapy during 12 months period.Materials and methods: The total study included 11 patients with PROL, manifesting in childhood. There were also examined 54 healthy volunteers (25 males and 29 females) aged 15–19 to determine the range of normal ...

IntroductionThe practice of screening for many chronic diseases, particularly endocrine pathology, is taking place all over the world. The relevance of screening increases significantly when we are talking about diseases with a torpid manifestation and absence of certain clinical symptoms in the debut. Such diseases include pathological conditions caused by pituitary hormone hypersecretion, in particular, acromegaly.The aim<p c...

IntroductionVitamin D (VitD) is thought to be essential for adequate testosterone (T) secretion in men. In the absence of D-hypovitaminosis, their blood T levels and T to estradiol (E2) ratio values are higher relative to those with VitD deficiency. The correlation between VitD levels and androgenization indices in men of different ages has not been practically studied.The aimTo study blood levels of T and th...

Introduction: Publications suggesting that thyroid nodules might be associated with insulin resistance (IR) and metabolic syndrome are quite interesting. The aim of the work is to analyze the association between anthropometric indicators IR and insulin-like growth factor-1 (IGF-1) in patients with nodular goiter. Methods Examined 73 patients with euthyroid single-node (n=34) and multinodular goiter (n=39), age (51.0&pm;10.6) years; determinin...

The aim of the study: To investigate the anti-proliferative effect of cabergoline (CAB) which was used in different regimes of suppressive therapy during 12 months in patients with prolactinoma (PROL).Subjects and methods: It was examined and underwent a 12 month course of treatment by selective dopamine agonist CAB 61 patients with PROL: microadenoma 42, macro&giant PROL - 19. (52 women/9 men) aged 16–66 years. The total duration of the disease...

Adipokine omentin is a connecting link between obesity and type 2 diabetes mellitus. It modulates insulin sensitivity of peripheral tissues and its secretion may change in the developed inflammation of adipose tissue at its excessive accumulation. Chemokine fractalkine is a marker of the development of inflammatory processes in the body. Objective: omentin and fractalkine contents in blood circulation depending on the degree if adipose tissue accumulation, waist circumference,...